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Efudex Cream (Flurouracil) belongs to a group of medications called antineoplastics. It is used topically to treat a type of skin cancer known as superficial basal cell carcinoma. It is also used to treat actinic keratosis, a skin condition that may lead to skin cancer. It works by killing the abnormal cells that are causing cancer or skin condition. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful to people to use this medication if their doctor has not prescribed it.
Wash the area to be treated with soap and water, then dry the area thoroughly. Apply the cream to the affected area twice a day with a nonmetal applicator (e.g., a cotton swab) or while wearing a suitable glove. Apply a thin layer, enough to cover the entire affected area of the skin. If fingertips are used to apply, wash your hands well with soap and water immediately afterward. Avoid contact with the eyes, eyelids, corners of the nose, mouth, easily irritated areas, or other areas where treatment is not intended. If you apply the medication near the eyes, nose, or mouth, take care to avoid getting the medication in these sensitive areas.
This medication will cause the skin to become severely inflamed and irritated, but continue to use it for the length of time recommended by your doctor, usually for 2 to 4 weeks. Complete healing of the treated area may take 1 to 2 months after stopping treatment. If the area becomes severely irritated, contact your doctor.
It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, apply it as soon as possible and continue with your regular schedule. If more than a few hours have passed, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor for advice.
Store this medication at room temperature and protect it from light, heat, and moisture. Keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Covering the affected area: Applying this cream and then covering it with a dressing that doesn't allow air to contact the skin may increase skin irritation caused by this medication. If you are unsure whether to cover the affected area, call your doctor for advice.
Contact your doctor if you experience these side effects and they are severe or bothersome
- Difficulty sleeping
- Effects where the cream is applied
- Peeling or scaling
- Skin discoloration
- Tenderness or soreness
- Medicinal taste in your mouth
- Sensitivity to the sun
- Sores around the mouth
- Watery eyes
Check with your doctor as soon as possible if any of the following side effects occur:
- Redness and swelling of normal skin
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Who should NOT take this medication?
Do not use fluorouracil if you are allergic to fluorouracil or any ingredients of the medication.
What other drugs could interact with this medication?
There may be an interaction between fluorouracil and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist.