Accolate (Zafirlukast) belongs to a group of medications known as leukotriene receptor antagonists. It works by blocking chemicals produced by the body called leukotrienes. Leukotrienes cause the lining of the breathing passages of the lung to swell. When used regularly, zafirlukast helps to reduce inflammation in the lining of the airways to make breathing easier. Zafirlukast is used for the prevention and chronic treatment of asthma in adults and children 12 years of age and older. It works over a long period of time to prevent asthma attacks but will not help to relieve an asthma attack when it is occurring. Asthma sufferers should always have their fast-acting asthma relief medication on hand to deal with attacks.
The recommended dose for adults and children aged 12 years and over is 20 mg twice daily taken on an empty stomach (at least one hour before or 2 hours after a meal). Continue to take this medication regularly, even when you are not having symptoms of asthma. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Before taking zafirlukast, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, alcohol use. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Older adults may be more sensitive to the side effects of this drug.Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- Abdominal pain
- Muscle aches
- Trouble sleeping
If you are an adult over 60 management or monitoring precaution:
Elderly may show less improvement in efficacy measures.
Giving Accolate to a child under 12 management or monitoring precaution:
Safety and efficacy not established in pediatrics age < 5 years. management or monitoring precaution: Monitor for neuropsychiatric and/or behavioral changes.
What form(s) does this medication come in?
Each white-to-off-white, round, biconvex, film-coated tablet, with surface markings, contains zafirlukast 20 mg. Nonmedicinal ingredients: croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and titanium dioxide.
Who should NOT take this medication?
Do not take zafirlukast if you: are allergic to zafirlukast or any ingredients of the medication have reduced liver function