Clobetasol is used in adults to treat moderate to severe plaque psoriasis. Clobetasol reduces the swelling, itching and redness that can occur with this condition. This medication is a very strong (super-high-potency) corticosteroid.

This medication is not recommended for use in children younger than 18 years of age due to an increased risk of side effects. Ask the doctor or pharmacist for details.

Use Clobex (clobetasol spray) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Use as you have been told, even if your signs get better.
• Do not take Clobex (clobetasol spray) by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
• Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
• Clean affected part before use. Make sure to dry well.
• Put a thin layer on the affected skin and rub in gently.
• Do not put on the face, underarms, or the groin area unless told to do so by the doctor.
• Do not use coverings (bandages, dressings, make-up) unless told to do so by the doctor.

Tell all of your health care providers that you take Clobex (clobetasol spray). This includes your doctors, nurses, pharmacists, and dentists.

Do not use to treat diaper rash.

Do not use Clobex (clobetasol spray) to treat acne, rosacea, or a rash around the mouth.

Use care when putting on a large part of the skin or where there are open wounds. Talk with the doctor.

Talk with your doctor before you use other drugs or products on your skin.

Do not put on cuts, scrapes, or damaged skin.

Do not use longer than you have been told by the doctor.

This medicine may cause harm if swallowed. If Clobex (clobetasol spray) is swallowed, call a doctor or poison control center right away.

This medicine may raise the chance of cataracts or glaucoma. Talk with the doctor.

This medicine may catch on fire. Do not use near an open flame or while smoking.

Use with care in children. Talk with the doctor.

This medicine may affect growth in children and teens in some cases. They may need regular growth checks. Talk with the doctor.

Some products are not approved for use in children. Talk with the doctor.

Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Clobex (clobetasol spray) while you are pregnant.

Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

If you are breast-feeding, do not put Clobex (clobetasol spray) right on the nipple or the area right around it.

This is not a list of all drugs or health problems that interact with Clobex (clobetasol spray).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Clobex (clobetasol spray) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of high blood sugar like confusion, feeling sleepy, more thirst, more hungry, passing urine more often, flushing, fast breathing, or breath that smells like fruit.
• Signs of Cushing's disease like weight gain in the upper back or belly, moon face, very bad headache, or slow healing.
• Signs of a weak adrenal gland like a very bad upset stomach or throwing up, very bad dizziness or passing out, muscle weakness, feeling very tired, mood changes, not hungry, or weight loss.
• Skin changes (pimples, stretch marks, slow healing, hair growth).
• Irritation where Clobex (clobetasol spray) is used.
• Thinning of the skin.
• Change in eyesight, eye pain, or very bad eye irritation.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Stinging.
• Dry skin.
• Burning.
• Redness.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• any type of active infection including measles, tuberculosis, herpes, or chickenpox
• circulation problems or vascular disease
• large areas of burned or damaged skin
• rosacea
• skin wasting or thinning
• an unusual or allergic reaction to clobetasol, corticosteroids, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Apply to clean dry skin. Use only enough to cover the affected areas. Do not use on healthy skin or over large areas of skin. Rub in gently but completely. Do not cover with a bandage or dressing unless your doctor or health care professional tells you to. Do not get this medicine in your eyes. If you do, rinse out with plenty of cool tap water. Do not use your medicine more often than directed or for longer than ordered by your doctor or health care professional. To do so may increase the chance of side effects.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Elderly patients are more likely to have damaged skin through aging, and this may increase side effects. This medicine should only be used for brief periods and infrequently in older patients.