Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat ankylosing spondylitis, gouty arthritis, rheumatoid arthritis, and severe osteoarthritis. This NSAID can be used to treat shoulder pain caused by bursitis or tendinitis as well. A suppository is a medicine that melts at body temperature and is inserted into the rectum. This drug can increase your risk of heart attack, stroke, and intestinal bleeding. Consult your doctor before taking to avoid severe side effects and drug interactions.

Refer to the medication guide before taking
Always follow your doctor’s directions

• Refrigerate suppository for 30 minutes if too soft to insert
• Unwrap foil and moisten the suppository
• Lay on your left side with the right knee bent
• Push the suppository into the rectum with your finger
• Remain lying down for a few minutes

Always tell your doctor if you have ever had:

• A heart attack, stroke, or blood clot
• Asthma
• Bleeding problems
• Fluid retention
• Heart disease
• High blood pressure
• Liver or kidney disease
• Stomach ulcers
• You are breastfeeding
• You are planning to conceive
• You are pregnant
• You are under 14 years old
• You smoke

Common side effects of Indomethacin:

• Dizziness
• Headache
• Indigestion
• Nausea

Side effects you should contact your doctor about:

• Anemia (low red blood cells): pale skin, cold hands and feet
• Changes in vision
• Heart problems: swelling, rapid weight gain, shortness of breath
• Kidney problems: little or no urination, fatigue or shortness of breath, swelling in the feet or ankles
• Liver or pancreas problems: jaundice, dark urine, fatigue, itching, flu-like symptoms, vomiting, diarrhea, loss of appetite, upper stomach and back pain
• Skin rash
• Stomach bleeding: blood stools, coughing up blood, vomit that looks like coffee grounds

What drugs can interact with Indomethacin Suppositories?

Many types of antidepressants can cause you to bruise or bleed easily when taken with this NSAID. Medications such as cyclosporine, lithium, methotrexate, and probenecid may interact with indomethacin. Blood pressure medications or blood thinners such as warfarin may not be suitable to be taken together. Other NSAIDs (aspirin, ibuprofen, naproxen, celecoxib, diclofenac, meloxicam, and others) should not be taken in conjunction with indomethacin. This list may not be complete, so always ask your doctor about the medications you are on before starting indomethacin.

What is indomethacin used for?

Indomethacin is used to relieve joint pain and stiffness caused by tendonitis, bursitis, and arthritis. Indomethacin is an anti-inflammatory drug that can reduce symptoms to help you resume daily activities.