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Linzess (Linaclotide) is used to treat certain types of bowel problems (irritable bowel syndrome with constipation, chronic idiopathic constipation). It works by increasing fluid in your intestines and helping speed up the movement of food through the gut. Linaclotide may improve stool texture and lessen symptoms such as bloating, abdominal pain/discomfort, straining, and feelings of incomplete bowel movements.
Take this medication by mouth on an empty stomach as directed by your doctor, usually once daily at least 30 minutes before your first meal of the day. Swallow the capsules whole. Do not break or chew the capsules.
If you have trouble swallowing the capsule, it may be opened and the contents mixed in a teaspoonful of applesauce. Swallow the mixture right away, without chewing it. Do not save the mixture for future use.
You may also empty the capsule's content into an ounce (30 milliliters) of water. Swirl the mixture for 20 seconds and drink right away, without chewing it. Add another ounce (30 milliliters) of water to the cup, swirl for 20 seconds and drink right away to get your whole dose. The water mixture may also be given through a tube into the stomach (nasogastric or gastric tube). If you are giving this medication through a tube, ask your health care professional for detailed instructions on how to give it.
The dosage is based on your medical condition and response to treatment.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
Tell your doctor if your condition does not improve or if it worsens.
This medication must not be used in children younger than 6 years because of the risk of serious side effects. Before taking linaclotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Diarrhea, bloating, gas, or stomach/abdominal pain/discomfort may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
How is Linzess different from a laxative?
Linzess was the first approved treatment in a class of drugs that works differently from other available medications. Linzess acts locally in the intestine and is thought to work in two ways: by helping to calm pain-sensing nerves† and by accelerating bowel movements. LINZESS helps you proactively manage your IBS C or CIC symptoms.
Why do I need to take Linzess daily?
Linzess was studied and shown to be effective when taken once daily. When taken daily as prescribed by your doctor, Linzess may help you proactively manage your symptoms of IBS C or CIC.
How do I know if Linzess is working for me?
It may be helpful to keep track of your symptoms by noting any changes you may be experiencing.
Is it common to experience diarrhea when starting Linzess?
Diarrhea is the most common side effect of Linzess, and it can sometimes be severe. Diarrhea often begins within the first 2 weeks of Linzess treatment. Stop taking LINZESS and call your doctor right away if you get severe diarrhea during treatment with Linzess.
What should I do if I experience any severe side effects?
Call your doctor or go to the nearest emergency room right away if you develop unusual or severe stomach-area (abdominal) pain, especially if you also have bright red, bloody stools or black stools that look like tar.
What if I missed a dose?
If you miss a dose, skip the missed dose. Take your next dose at a regular time. Do not double the dose to catch up.
How should I store it?
Store in the original container at room temperature away from light and moisture. To help protect from moisture, keep the desiccant in the tightly closed container. Do not store it in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.