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Premarin (conjugated estrogen) is a female hormone. It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using estrogen pills such as Premarin to treat symptoms only in and around the vagina such as vaginal dryness, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected.
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Take this medication by mouth with or without food as directed by your doctor. You may take it with food or right after a meal to prevent stomach upset.
If you are taking the extended-release tablets, do not crush, chew, or dissolve them. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
The dosage is based on your medical condition and response to treatment.
Before using this medication, tell your doctor or pharmacist your medical history especially of vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).
Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.
Common Premarin side effects include:
-Headache or weight changes may occur.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Tell your doctor right away if you have any Premarin serious side effects, including:
-Mental/mood changes (such as depression, memory loss)
-Unusual vaginal bleeding (such as spotting, breakthrough bleeding
-Increased or new vaginal irritation/itching/odor/discharge
-Severe stomach/abdominal pain
Q: What does Premarin contain?
A: Premarin contains a mixture of conjugated estrogens, which are a mixture of sodium estrone sulphate and sodium equilin sulphate and other components, including sodium sulphate conjugates, 17α-dihydroequilin, 17α-estradiol, and 17ß-dihydroequilin.1 This is not a comprehensive list of ingredients.
Q: What dosage strengths are available for Premarin?
A: Premarin is available in 5 dosage strengths (range spans from 0.3 mg to 1.25 mg).1 Estrogens, with or without progestins, should be prescribed at the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. In some cases, hysterectomized women with a history of endometriosis may need a progestin.
Q: What are the contraindications for Premarin?
A: Premarin should not be used in women with any of the following conditions: undiagnosed abnormal genital bleeding; known, suspected, or a history of breast cancer; known or suspected estrogen-dependent neoplasia; active deep vein thrombosis, pulmonary embolism, or a history of these conditions; active arterial thromboembolic disease (eg, stroke, myocardial infarction), or a history of these conditions; anaphylactic reaction or angioedema with PREMARIN; liver impairment or disease; thrombophilic disorders; known or suspected pregnancy.1