Rybelsus (semaglutide) tablets are used to control blood sugar levels in adults with type 2 diabetes mellitus. Rybelsus belongs to a class of medications called glucagon-like peptide-1 (GLP-1) receptor agonists. Medications in this class increase insulin release and decrease glucagon secretion. When used alongside proper diet and exercise, this ultimately leads to better blood sugar control. [1]

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To ensure optimal results when taking Rybelsus, it’s crucial to follow the directions provided by your healthcare professional. For your convenience, we’ve included FDA-recommended instructions below:

• Take Rybelsus once daily at the same time each day.
• Use a maximum of 4 ounces of plain water to swallow the tablet.
• Take Rybelsus at least 30 minutes before consuming any food, water, or other oral medications for the day.
• Swallow the tablet whole and do not cut, crush, or chew it.
• If you forget to take a dose, skip the missed dose, and resume your regular dosing schedule the following day. [1]

Consult your healthcare professional for guidance if you have any further questions or concerns.

Before starting Rybelsus, inform your physician of any medical conditions, especially if you have a history of pancreatitis or diabetic retinopathy. In addition, ensure you disclose all medications you’re currently taking, as they may interact with Rybelsus.

If you are planning a pregnancy in the next two months, are currently pregnant, or are breastfeeding, Rybelsus may not be suitable for you as it may cause harm to your baby. It’s important to discuss alternative options with your physician. [1]

Common side effects include:

• Nausea
• Abdominal pain
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation [1]

In rare cases, you may experience serious side effects, such as:

• Pancreatitis 
• Diabetic retinopathy
• Hypoglycemia
• Acute Kidney Injury
• Hypersensitivity [1]

If you experience any serious or persistent side effects, please contact your healthcare provider so they can provide you with the best course of action.

What’s the recommended dose of Rybelsus?

Typically, Rybelsus is prescribed in a gradual escalation. Your physician may start you on 3 mg once daily for 30 days. Afterward, they may increase your dose to 7 mg once daily. If you require further glycemic control after 30 days on 7 mg, your physician may increase your dose to 14 mg once daily. [2]

What should I do if I miss a dose?

If you miss a dose of Rybelsus, skip the missed dose and continue with your regular dosing schedule the following day. [1]

Can individuals with type 1 diabetes take Rybelsus? 

Rybelsus is specifically approved for treating type 2 diabetes and should not be used by individuals with type 1 diabetes. Consult your healthcare provider for appropriate treatment options for type 1 diabetes. [1]

Is Rybelsus suitable for individuals with a history of pancreatitis?

Rybelsus has not yet been studied in individuals with pancreatitis. Because of this, if you have a history of pancreatitis or are experiencing associated symptoms, it’s crucial to inform your healthcare provider before starting Rybelsus. Your physician may recommend alternative antidiabetic medications. [1]